The Urinary Excretion of 17 - Ketosteroids

ERS Helen W. Belding,M.D., 1I’inston-Satem, N. C. Conrad Maier, M.D., Zurich, Switzerland Sheila T. Callender, M.D.,Oxford, England Milos Netou ek, M.D., Prague, Czechoslovakia Robert B. Chodos, M.D. Franiinghain .lfass. Charles E. Rath, M.D., Washington . . . Jean P. Soulier, M.D. Paris, France Roger C. Crafts Ph.D., Cincinnati Ram#{243}nM. Su#{225}rezM.D. San Juan, Puerto Rico C. R. DasGupta, M.D., Calcutta, India Timothy H. Talbot, Jr., M.D., New York Solomon Estren, M.D., New York Philip F. Wagley, M.D., Baltimore Oliver P. Jones, Ph.D., Buffalo Jan Waldenstr#{246}m, M.D.. Upsala, Sweden NEOPLASTIC LEUKOCYTIC DISEASE TRIETIIYLENE MEI.AMINE IN TI-fE TREATMENT OF HoooKns’s DISEASE AND ALLIED NE01u. tSMS. (‘. P. Rhoads, 1). .1 . Karnofsky, J. .1 . Burchenal and L. F. Craver. From Memorial Camscer Ceniter, New York, N. V. Tr. A. Ani. Physicianis, 63: 136-146, 1950. Tue effects of aml(l ini(hcations for the use of triethvlene nselamine (TE \1) are discussed in t lie light of t lie aut hors’ experience. \\‘hien giveni inst raveiiously in doses of 2 to 3 nig., Ti\I rarely produced nausea or vonsiting, whereas at higher (loses nuausea did occur anid persisted longer than that caused by HN 2. Pancytopenia was produced as a delayed toxic effect. Oral a(lminuistratiomi of the drug ins doses of 5 nig. may produce nausea amid vomiting eight to fifteen hours later. \Iaximsium marrow (lepressioni may not occur until sevens to fourteen days after the last (lose. The initial dose is thus usually 10 nig. giveni iii two to four (lays. Lvnnphatic leukemia usually responds to smiiall (loses, :111(1 5 nig. are given as the inuitial dose ins this comi(hit iomi. 1):st a a re l)resent (‘(1 for 15 i) tt ient s wit is lIo(.Igki n ‘s (lisease (14 showed some iniproveinenit ) , 4 wit h chronic myelogemsous leukeniia (3 iniproved ) , 6 wit h chronic lyniphatic leukensia (5 insprove(l ) :111(1 variety of allied conditionus. I-IN imi(hicated whemi rapi(l cont rol is (lesiral)le. The oral adnsinist ration of trietisylene nielansimie produces results (lualitativelY simssilar to the effects of HN. , i)ut the ease of adliii must rat iou , t lie l)OS5I 1)il i t V of musaintenance t hierapy t he lesser miausea anud vomiting and the slower ansi.! nusore )rolonged forni of the oral t reatnient niake it a drug of potential value. -T.R.T.,Jr. TUE PROTE(’TIVE lFFE(T OF CYSTEINE ON LEU(ou’ENmA INu)UCED BY NITROGEN MUSTARD. .1 . S. Weisberger and I?. ElY. Heinle. From the Department of Medicine, Lakeside Hospital an(l the School of Medicine, Western Reserve University, Cleveland, Ohio. J. Lab. & Clims. Med. 36: 872-876, 1950. Cyst einue hydrochloride injected mtraperitoneahly into rabbits, in doses of 650 to 1000 nig. per Kg. body weight tens to fifteen minutes h)efore injecting HN2, 2.5 mg per Kg. body weight intravenously, resulted in partial Protect 100 against leukopenia. There was no such protectiomu wheni cysteine was injected immediately after HN2. When 25 mg. of HAL per Kg. body weight was inijected intramuscularly one hour before HN2, no l)rOtectiOfl against leukopenia was afforded. No statement is made concerning what factors were taken into account ins (leci(hinsg the tinse intervals so employed. The possibility of clinical applications of these findinugs is considered.-T.R.7’.,Jr. For personal use only. on October 3, 2017. by guest www.bloodjournal.org From